Decreased body weight gains were observed in both sexes of the 71-ppm group, and a slight decrease was also observed in females of the 41-ppm group. Somade OT, Ajayi BO, Adeyi OE, Adeshina AA, James AS, Ayodele PF. J Adv Pharm Technol Res. The EPA, A poly(dimethylsiloxane) type silicone oil containing gamma-mercaptopropyl groups was evaluated for acute toxicity. Dermally administered glycol ethers were metabolized differently than glycol ethers administered in drinking water (M. A. Medinsky, G. Singh, W. E. Bechtold, J. Later symptoms may include a decreased level of consciousness, headache, and seizures. Information on the nature of the peer review and availability of the source documents is presented in Appendix 1. In a subsequent study, rats were exposed for 9 days (6 hr/day) to EGBE concentrations of 245, 86, 20, or 0 (control) ppm. Criteria for a Recommended Occupational Exposure Standard for Ethylene Glycol Monobutyl Ether and Ethylene Glycol Monobutyl Ether Acetate—DHHS (NIOSH) No. Studies on ethylene glycol alkyl ethers and related compounds administered to mice by oral gavage revealed the occurrence of testicular atrophy and decreased white blood cell count by EGM, … Its potential for bioaccumulation is low. Transient eye irritation and barely perceptible skin irritation were among, We tried out the potential irritant and sensitizing effect of the main glycol ethers found in industrial and consumer products. The mechanism of testicular atrophy induced by low ethylene glycol mono alkyl ethers is likely to be an inhibitory action on cell division. A tolerable concentration of 0.04 mg/m has also been derived based on the benchmark concentration for hyperplasia of the forestomach in mice. In a subsequent study, rats were exposed to mean EGHE concentrations of 0 (control), 20, 41, or 71 ppm for 6 hr/day, 5 days/week, for 13 weeks. The urinary tract of all animal species used in biomedical research may exhibit a variety of pathologic entities. . 14C-DGBA was rapidly absorbed from the gastrointestinal tract and eliminated predominantly in rat urine within 24 h following oral administration at 200 or 2000 mg/kg. Effects on peripheral blood, testes, and sperm have been reported at occupational exposure levels ranging between 0.4 and 10 ppm EGME in air, and with additional, possibly substantial, dermal exposure. COVID-19 is an emerging, rapidly evolving situation. Toxicology. At ambient conditions, the low vapor pressure of ethylene glycol monohexyl ether (EGHE) allows for a maximum vapor concentration of approximately 85 ppm. Levels of airborne 2-butoxyethanol in occupational settings are typically in the mg/m3 range. Notice of Proposed Rulemaking Title 22, Section 12805 Specific Regulatory Levels Causing Reproductive Toxicity: ethylene glycol monoethyl ether (EGEE), ethylene glycol monoethyl ether acetate (EGEEA) and potassium dimethyldithiocarbamate the observations. The effects on the rat testis of single inhalation exposures to ethylene glycol monoalkyl ethers, in particular ethylene glycol monomethyl ether. The subject kept two or four fingers immersed in neat butoxyethanol for 2 h. Arterialized capillary blood samples were collected from the other hand before, during, and up to 4 h after the exposure and analyzed for butoxyethanol by gas chromatography.  |  Due to the lack of quantitative assessments of respiratory exposures to airborne irritants and sensitizers among professional cleaners, the culpable substances have yet to be identified.Purpose: Focusing on previously identified irritants, our aims were to determine, The 24 day LDââ of monosodium methanearsonate (MSMA) for New Zealand white rabbits was estimated to be 102 mg MSMA/kg body weight. Toxicity and death may occur after drinking even a small amount. OSTI.GOV Journal Article: Acute and subchronic toxicity of ethylene glycol monobutyl ether Title: Acute and subchronic toxicity of ethylene glycol monobutyl ether Full Record toxicity was also evaluated for each glycol ether in several in vitro and in vivo assays. The animals were observed for a period of 2 weeks for signs of toxicity following the exposure. Cutaneous irritation was determined in the rabbit following the EEC method (European Economic Communities) and the Draize protocol, and the sensitizing effect was evaluated in the guinea pig by the maximized Magnusson and Kligman method. In animals, adverse effects on reproduction and development have not been observed at less than toxic doses. Access scientific knowledge from anywhere. KRASAVAGE, W. J. There is less confidence in this value, however, due to the paucity of information on mode of induction and, hence, relevance to humans. They are used in paints, lacquers, stains, inks and surface coatings, silk-screen printing, photographic and photo lithographic processes, for example, in the semiconductor industry, textile and leather finishing, production of food-contact plastics, and as an antiicing additive in hydraulic fluids and jet fuel. No alterations of the hematology parameters or the morphology of the testes or liver were observed. CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): The available information on the acute and subchronic toxicity of ethylene glycol monobutyl ether is reviewed. Although only detected once, EGBE air concentrations (n = 4) were high (49.48-58.72mg m(-3)), and close to the Swiss OEL (49mg m(-3)). ETHYLENE GLYCOL MONOBUTYL ETHER EGM CAUTIONARY RESPONSE INFORMATION Common Synonyms Oily liquid Colorless Mild rancid odor Floats and mixes with water. The available information on the acute and subchronic toxicity of ethylene glycol monobutyl ether is reviewed. Toxicol Rep. 2020 Jun 23;7:779-787. doi: 10.1016/j.toxrep.2020.06.007. In addition to ME and MAA, only MEA, which was as effective as ME, suppressed the PFC response to TNP-LPS. A tolerable concentration of 11 mg/m has been derived, based upon the benchmark concentration for hematological effects in rats, quantitatively taking into account experimental data on interspecies variations in kinetics and dynamics. IRIS assessment development process. Based on limited data from case reports and one laboratory study, similar acute effects - including haemolytic effects as well as effects on the central nervous system - are observed in humans and rats exposed to 2-butoxyethanol, although the effects are observed at much higher exposure concentrations in humans than in rats. It is not known whether chronic or repeated exposure to ethylene glycol increases the risk of reproductive toxicity or developmental toxicity. Function and uses EGBE belongs to the group of glycol ethers, which are mainly used as solvents. 2-Butoxyethanol is an organic compound with the chemical formula BuOC2H4OH. In several studies, increased frequency of spontaneous abortions, disturbed menstrual cycle, and subfertility have been demonstrated in women working in the semiconductor industry. During 2003, the production of EGBE in the European Union was approximately 161,000 tonnes. 2005 Mar 28;156(1):13-28. doi: 10.1016/j.toxlet.2003.08.010. However, more realistic assumptions based on the available data suggest that risk to aquatic organisms is low. Mice were given various doses (62.5, 125, 250, 500, 1,000, 2,000 and 4,000 mg/kg body weight) of the compounds daily for 5 days/week, for 5 weeks. In the 2-week studies, groups of five male and five female rats and mice received 2-methoxyethanol, 2-ethoxyethanol, or 2-butoxyethanol in the drinking water. All propylene glycol ethers are currently believed to be relatively safe; most ethylene glycol ethers with "methyl" in their names are relatively toxic. Chronic or repeated exposure to ethylene glycol may lead to irritation of the throat, mild headache, low backache, loss of consciousness, and nystagmus, all of which resolve if the source of exposure is removed. 2-Butoxyethanol has been assessed as a Priority Substance under the Canadian Environmental Protection Act. Toxicities of ethylene glycol (EG) and 6 ethylene glycol mono alkyl ethers administered orally were studied. The etiology and pathogenesis of lesions in some conditions is well understood, but in many other entities and in some species, the study of the pathology of the urinary tract is in its infancy. Decreased body weight gains and increased liver weights were also found.  |  Thus, exposure of rats and rabbits to EGHE vapor during the period of organogenesis produced maternal toxicity at near-saturation vapor concentrations (79.2 ppm), but no evidence for developmental toxicity or teratogenicity. ETHYLENE GLYCOL MONOBUTYL ETHER (EGBE) (CAS No. Sections I (Health Hazard Assessments for Noncarcinogenic Effects) and 57, pp. EGMEA is rapidly converted to EGME in the body and the two substances are equally toxic in animals. 102, 443–455). The percutaneous absorption of the commonly used glycol ether 2-butoxyethanol (ethylene glycol monobutyl ether) was investigated in 12 exposure experiments with five men. Stability No data submitted 3.2. There were no significant biological effects in rats exposed subchronically to 25 or 5 ppm. Environ Health Perspect. 2-Butoxyethanol has moderate acute toxicity and is irritating to the eyes and skin; it is not a skin sensitizer. Toxic doses being expressed as mg/kg body weight, esterification seemed to weaken the atrophic action of EGM and EGE, but when expressed as mol/kg, significant difference was found neither between EGM and EGMA nor between EGE and EGEA. Most intoxications are associated with ingestion of antifreeze, which is typically 95% EG. The mechanism of ethylene glycol ether reproductive and developmental toxicity and evidence for adverse effects in humans. Ethylene glycol monobutyl ether (EGBE) (2-Butoxyethanol); CASRN 111-76-2. Many lesions have been described only in morphologic terms and without good clinical histories and laboratory work-ups. Ethylene glycol poisoning is poisoning caused by drinking ethylene glycol. Concomitant administration of the alcohol dehydrogenase inhibitor 4-methylpyrazole with ME or MEA prevented suppression of the PFC response by these glycol ethers. Pharmacol. The in vitro hydrolysis of DGBA in rat blood and its in vivo metabolism and disposition in male Sprague-Dawley rats were studied. No evidence was found for excretion of 2-butoxyacetic acid, which has been shown to exert haematological effects in rats. The alkoxyacetic acid was a major metabolite for all three glycol ethers. The available information on the acute and subchronic toxicity of ethylene glycol monobutyl ether is reviewed. 2016 Dec;36(12):1614-1621. doi: 10.1002/jat.3326. There were no treatment-related effects with respect to hematology, necropsy, or gestational parameters and no significant change in the incidence of malformations or variations (expressed as total, individual, external, visceral, or skeletal). (1986). Washington, DC In view of recent findings with other chemically related glycol ethers, particular attention has been given to possible adverse effects on blood and testicular tissue. Bond, P. J. Sabourin, L. S. Birnbaum, and R. F. Henderson, 1990, Toxicol. Hepatic oxidative stress, up-regulation of pro-inflammatory cytokines, apoptotic and oncogenic markers following 2-methoxyethanol administrations in rats. The average size of the rabbit dermal irritant patch tests was 1.0, indicating that MSMA is a mild irritant to intact skin. 111-76-2 - POAOYUHQDCAZBD-UHFFFAOYSA-N - Ethylene glycol mono-n-butyl ether - Similar structures search, synonyms, formulas, resource links, and other chemical information. 2-Butoxyethanol is used widely as a solvent in surface coatings, such as spray lacquers, quick-dry lacquers, enamels, varnishes, varnish removers, and latex paint. The elimination kinetics of 2-butoxyethanol (ethylene glycol monobutyl ether, EGBE) were studied in the once-through isolated perfused rat liver system in the presence and absence of ethanol. Would you like email updates of new search results? Integrated Risk Information System (IRIS) March 2010 . The subtle hematologic findings of these studies confirm the known RBC perturbations of EGBE. Polyethylene Glycol: Polyethylene glycol is a polyether compound, meaning that it has many ether groups. It is extensively used in aerosols and cleaning agents intended for household use. The results indicate that persons exposing large portions of their skin to butoxyethanol are at risk of absorbing acutely toxic doses. Ethylene glycol monomethyl ether-induced testicular oxidative stress and time-dependent up-regulation of apoptotic, pro-inflammatory, and oncogenic markers in rats. Butyl Glycol Ether Revision Date 03/04/2015 Version 1.0 Print Date 03/04/2015 110000002553 Page 1 of 9 SAFETY DATA SHEET SECTION 1 IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING Trade name Butyl Glycol Ether Synonyms Butyl cellosolve, Ethylene glycol monobutyl ether Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data, as outlined in the . Dose-responce relation was found in these effects. When substances were not noted as present in safety data sheets of cleaning products used but were measured, air concentrations showed no presence of MEA, while the glycol ethers were often present, and formaldehyde was universally detected. It is liable to form peroxides on exposure to air and light. NLM Effects of repeated application of EGBE to the skin of rabbits. This CICAD was approved as an international assessment at a meeting of the Final Review Board, held in Berlin, Germany, on 26-28 November 1997. USA.gov. Rabbit maternal toxicity occurred at 79.2 ppm as transient weight gain reduction during the exposure period. Effects of repeated inhalation exposures to EGBE in laboratory animals. Arch Toxicol Suppl. cutaneous hypertensitivity, and all glycol ethers studied were classified from slightly irritant to severely irritant according to the Draize protocol, though only 2-butoxyethanol and isopropoxyethanol were classified as skin irritants with the EEC method. In the presence of 17.1 mm ethanol (0.1%) the extraction ratio of EGBE decreased from 0.44 to 0.11. ETHYLENE GLYCOL N-BUTYL ETHER may react with bases, aluminum and oxidizing materials. Many of the lesions have been reported in single or small numbers of animals. In general, administration in drinking water enhanced the production of ethylene glycol and glycol ether-derived CO2. EGM was more effective than EGE, while ethylene glycol mono butyl ether and ethylene glycol mono phenyl ether had but slight effect and EG had no detectable action on testis and leucocytes. A. Metabol Open. Timed pregnant Fischer 344 rats and New Zealand White rabbits were exposed to vapor from ethylene glycol monohexyl ether (EGHE, CAS No. This colorless liquid has a sweet, ether-like odor, as it derives from the family of glycol ethers, and is a butyl ether of ethylene glycol. 3. The glycol ethers methoxyethanol (ME), ethoxyethanol (EE), and butoxyethanol (BE) are widely used in industrial and house-hold products. review reported a dermal study carried out on 6 adult male rabbits. General Formula. Ethylene Glycol: The general formula for ethylene glycol is C 2 H 6 O 2. Feces and exhaled CO2 represented minor routes of excretion. Clipboard, Search History, and several other advanced features are temporarily unavailable. Glycol ethers should be handled with all the care that should be taken in the safe use of organic solvents. 185-191, 1984 Acute and Subchronic Toxicity of Ethylene Glycol Monobutyl Ether by Tipton R. Tyler* The available information on the acute and subchronic toxicity ofethylene glycol monobutyl ether is Average size of the rabbits were exposed to ethylene glycol ( EG ) and ethylene oxide intoxications associated! Clipped skin areas of the complete set of features central nervous System, kidneys, and liver occur at exposure! 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